Not much is known of Twiztid's past before his association with the Great Hohenheim of Light and the Tragedy of Xerses but he made his claim to the stone after the battle for Amestris. After a questionable decision made by his half-brother Zoot, he was forced to cross the Door of Truth and thus lost his right arm and left leg in the process.

After showing up on the Rockbell's automail shop and getting back on his feet, he left Resembool to seek a vessel for Zoot and along the way he has made a name for himself as an accomplished alchemist and protector of the the stone.

He now resides in the Attic and works with Eizen to protect his friends and family from those who seek to destroy it.